XYLYX BIO, INC.
BROOKLYN, NY
What changed
Phase II trial registered: Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
4w agoTrial registeredJun 16, 2026Source filing (opens the source filing in a new tab)
Momentum
Momentum 100 out of 100, unchanged since the last recompute.
Accelerating: several high-weight events landed recently.
Runway (estimate)
No disclosed raise on file, so there is nothing to model from.
Stage
Phase II
The furthest-along thing in the public record. Not a projection.
Runway is an estimate: the last disclosed raise (SEC Form D) minus a modeled burn rate for the company’s stage and therapeutic area. It is not a disclosure, and companies routinely raise non-dilutive money we can’t see. How this is calculated.
Grant to raise
Every record Biodatica has resolved onto this company, newest first, each linked to the filing it came from. Where a source publishes no stable deep link for a record, the identifier is shown so you can look it up yourself.
- Trial
PHASE2 registered
Mar 1, 2027Knee Osteoarthritis, Pain, Depression · NOT_YET_RECRUITING · sponsor: VA Office of Research and Development · Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
ClinicalTrials.gov · NCT07649291 (opens the source filing in a new tab)
- Grant
R44 · $1.5M · non-dilutive
Sep 8, 2025XYLYX BIO, INC. · PI O'NEILL, JOHN DAVID · NHLBI · award ends Jun 30, 2027 · Translational development and clinical evaluation of a bioengineered human lung graft for clinical transplantation
NIH RePORTER · NIH RePORTER 11256353 (opens the source filing in a new tab)
- Grant
R37 · $511k · non-dilutive
Sep 1, 2025CASE WESTERN RESERVE UNIVERSITY · PI O'NEILL, WENDI QUINN · NCI · award ends Aug 31, 2030 · Biological factors driving clinical outcomes in HPV+ oropharyngeal cancer
NIH RePORTER · NIH RePORTER 11204140 (opens the source filing in a new tab)
- Grant
R01 · $663k · non-dilutive
Aug 1, 2025GEORGETOWN UNIVERSITY · PI SCHWARTZ, MARC D · NCI · award ends Jul 31, 2030 · Proactive Outreach and Streamlined Genetic Testing in Prostate Cancer Survivors
NIH RePORTER · NIH RePORTER 11230461 (opens the source filing in a new tab)
- Grant
R01 · $547k · non-dilutive
May 1, 2025GEORGETOWN UNIVERSITY · PI O'NEILL, SUZANNE C. · NCI · award ends Apr 30, 2030 · Bundled Multicancer Screening and Genetic Services Navigation to Improve Cancer Outcomes
NIH RePORTER · NIH RePORTER 11116110 (opens the source filing in a new tab)
- Grant
R01 · $704k · non-dilutive
Apr 1, 2025UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN · NCI · award ends Mar 31, 2030 · Family RESPOND: Defining the Genetic Basis of Prostate Cancer Risk in African American Families
NIH RePORTER · NIH RePORTER 11310151 (opens the source filing in a new tab)
- Grant
R61 · $265k · non-dilutive
Sep 23, 2024UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'NEILL, JOSEPH · NIAAA · award ends Aug 31, 2026 · Trigeminal Nerve Stimulation for Prenatal Alcohol Exposure
NIH RePORTER · NIH RePORTER 11196725 (opens the source filing in a new tab)
- Grant
P20 · $130k · non-dilutive
Sep 5, 2024WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · NCI · award ends Aug 31, 2026 · Administrative Core
NIH RePORTER · NIH RePORTER 11184206 (opens the source filing in a new tab)
- Grant
R44 · $968k · non-dilutive
Sep 1, 2024XYLYX BIO, INC. · PI O'NEILL, JOHN DAVID · NIDDK · award ends Aug 31, 2027 · Liver fibrosis cell-based assay platform: integrating patient-derived fibrotic liver ECM with primary stellate cells, Kupffer cells, and hepatocytes to accelerate anti-fibrotic drug development
NIH RePORTER · NIH RePORTER 11249098 (opens the source filing in a new tab)
- Trial
NA registered
Jul 31, 2024Hereditary Cancer, Genetic Testing · RECRUITING · sponsor: Rutgers, The State University of New Jersey · Addressing Genomic Disparities in Cancer Survivors
ClinicalTrials.gov · NCT06073626 (opens the source filing in a new tab)
- Grant
R44 · $966k · non-dilutive
Jun 6, 2024XYLYX BIO, INC. · PI O'NEILL, JOHN DAVID · NCI · award ends May 31, 2027 · Multi-organ metastatic breast cancer cell-based assay platform that models organotropic metastases using patient organoids in human tissue-derived ECMs to accelerate anti-metastatic drug development
NIH RePORTER · NIH RePORTER 11109706 (opens the source filing in a new tab)
- Trial
NA registered
Jun 3, 2024Post-COVID Conditions, Obesity · RECRUITING · sponsor: VA Office of Research and Development · Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
ClinicalTrials.gov · NCT05880108 (opens the source filing in a new tab)
- Grant
P01 · $71k · non-dilutive
Feb 13, 2024WAYNE STATE UNIVERSITY · PI BEEBE-DIMMER, JENNIFER L · NCI · award ends Jan 31, 2030 · Project 2
NIH RePORTER · NIH RePORTER 11287874 (opens the source filing in a new tab)
- Grant
P01 · $227k · non-dilutive
Feb 13, 2024WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · NCI · award ends Jan 31, 2030 · Core 1
NIH RePORTER · NIH RePORTER 11287882 (opens the source filing in a new tab)
- Grant
P01 · $52k · non-dilutive
Feb 13, 2024WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · NCI · award ends Jan 31, 2030 · Admin Core
NIH RePORTER · NIH RePORTER 11287879 (opens the source filing in a new tab)
- Grant
P01 · $612k · non-dilutive
Feb 13, 2024WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · NCI · award ends Jan 31, 2030 · Genetic Variation in Cancer Risk and Outcomes in African Americans
NIH RePORTER · NIH RePORTER 11287871 (opens the source filing in a new tab)
- Grant
R01 · $722k · non-dilutive
Feb 1, 2024VANDERBILT UNIVERSITY MEDICAL CENTER · PI BACCHETTA, MATTHEW DOMINIC · NHLBI · award ends Jan 31, 2028 · The Road to Destination Therapy: Developing a Durable Ambulatory Mechanical Cardiopulmonary Support for Pulmonary Hypertension
NIH RePORTER · NIH RePORTER 11261531 (opens the source filing in a new tab)
- Grant
R35 · $927k · non-dilutive
Sep 1, 2023GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE · NCI · award ends Aug 31, 2030 · Investigations CONNECTing Cancer and Aging (I-CONNECT)
NIH RePORTER · NIH RePORTER 11172553 (opens the source filing in a new tab)
- Grant
R01 · $780k · non-dilutive
Jun 15, 2023UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARROLL, JUDITH E · NIA · award ends Feb 29, 2028 · Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related Dementias
NIH RePORTER · NIH RePORTER 11306080 (opens the source filing in a new tab)
- Grant
R01 · $652k · non-dilutive
May 5, 2023COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LLANOS, ADANA A. M. · NIMHD · award ends Nov 30, 2027 · Assessing Cervical Cancer Healthcare Inequities in Diverse Populations: The ACHIEVE Study
NIH RePORTER · NIH RePORTER 11424416 (opens the source filing in a new tab)
- Grant
R01 · $620k · non-dilutive
Mar 9, 2023RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KINNEY, ANITA Y. · NCI · award ends Jan 31, 2028 · Addressing Genomic Disparities in Cancer Survivors
NIH RePORTER · NIH RePORTER 11263647 (opens the source filing in a new tab)
- Grant
I01 · non-dilutive
Oct 1, 2022BALTIMORE VA MEDICAL CENTER · PI RYAN, ALICE S. · VA · award ends Sep 30, 2026 · Home-Based Exercise Tele-Rehabilitation in High-Risk Veterans: Impact of COVID-19 Exposure and Socioeconomic Factors
NIH RePORTER · NIH RePORTER 11305968 (opens the source filing in a new tab)
- Grant
R33 · $759k · non-dilutive
Sep 30, 2022GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE · NIA · award ends Apr 30, 2027 · I-REACH (Infrastructure for REsearch on Cancer and Aging)
NIH RePORTER · NIH RePORTER 11169001 (opens the source filing in a new tab)
- Grant
R33 · $774k · non-dilutive
Sep 30, 2022GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE · NIA · award ends Apr 30, 2027 · I-REACH (Infrastructure for REsearch on Cancer and Aging)
NIH RePORTER · NIH RePORTER 11377972 (opens the source filing in a new tab)
- Grant
R01 · $372k · non-dilutive
Sep 20, 2022COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LLANOS, ADANA A. M. · NCI · award ends Aug 31, 2026 · Impact of Allostatic Load and Neighborhood Contextual Factors on Breast Cancer in the Women's Health Initiative
NIH RePORTER · NIH RePORTER 11373145 (opens the source filing in a new tab)
- Grant
IK6 · non-dilutive
Jul 1, 2022BALTIMORE VA MEDICAL CENTER · PI RYAN, ALICE S. · VA · award ends Jun 30, 2029 · RR&D Research Career Scientist Award Application
NIH RePORTER · NIH RePORTER 11092767 (opens the source filing in a new tab)
- Grant
R01 · $662k · non-dilutive
Apr 1, 2022RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KINNEY, ANITA Y. · NHLBI · award ends Mar 31, 2027 · TELEhealth Shared decision-making COaching for lung cancer screening in Primary care (TELESCOPE)
NIH RePORTER · NIH RePORTER 11311265 (opens the source filing in a new tab)
- Grant
T32 · $258k · non-dilutive
Aug 1, 2021GEORGETOWN UNIVERSITY · PI O'NEILL, SUZANNE C. · NCI · award ends Jul 31, 2026 · Training Program in Cancer Population Science (CaPS)
NIH RePORTER · NIH RePORTER 11160625 (opens the source filing in a new tab)
- Grant
K00 · $93k · non-dilutive
Aug 3, 2020UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'NEILL, KATHLEEN · NCI · award ends Jul 31, 2026 · Lysosomal metabolism as a targetable driver of pancreatic cancer
NIH RePORTER · NIH RePORTER 11139572 (opens the source filing in a new tab)
- Trial
NA registered
May 1, 2020BRCA1 Mutation, BRCA2 Mutation · ENROLLING_BY_INVITATION · sponsor: Georgetown University · Genetic Education in BRCA Families
ClinicalTrials.gov · NCT03544983 (opens the source filing in a new tab)
- Grant
UG1 · $471k · non-dilutive
Aug 7, 2019GEORGETOWN UNIVERSITY · PI ADAMS-CAMPBELL, LUCILE L. · NCI · award ends Jul 31, 2026 · National Capital Area (NCA) NCI Community Oncology Research Program (NCORP)
NIH RePORTER · NIH RePORTER 11336619 (opens the source filing in a new tab)
- Grant
U01 · $103k · non-dilutive
Feb 27, 2017WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · NCI · award ends Feb 28, 2027 · Detroit Research on Cancer Survivors (Detroit ROCS)
NIH RePORTER · NIH RePORTER 11396745 (opens the source filing in a new tab)
- Grant
U01 · $1.1M · non-dilutive
Feb 27, 2017WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G. · NCI · award ends Feb 28, 2027 · Detroit Research on Cancer Survivors (Detroit ROCS)
NIH RePORTER · NIH RePORTER 11287860 (opens the source filing in a new tab)
- Trial
NA registered
Feb 15, 2017Breast Density, Breast Cancer Female · COMPLETED · sponsor: Georgetown University · ENGAGED 2 Study: Experiences With Mammography Screening and Breast Density 2
ClinicalTrials.gov · NCT03029286 (opens the source filing in a new tab)
- Grant
P30 · $212k · non-dilutive
Apr 15, 2011UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'NEILL, MARIE SYLVIA · NIEHS · award ends Mar 31, 2027 · Integrated Health Sciences Core
NIH RePORTER · NIH RePORTER 11060060 (opens the source filing in a new tab)
- Grant
P30 · $202k · non-dilutive
Apr 15, 2011UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'NEILL, MARIE SYLVIA · NIEHS · award ends Mar 31, 2027 · Integrated Health Sciences Core
NIH RePORTER · NIH RePORTER 11362350 (opens the source filing in a new tab)
- Grant
P30 · $207k · non-dilutive
Sep 15, 2006UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · NIA · award ends Jun 30, 2027 · Applied Physiology and Mechanisms
NIH RePORTER · NIH RePORTER 11134599 (opens the source filing in a new tab)
- Grant
P30 · $1.2M · non-dilutive
Sep 15, 2006UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · NIA · award ends Jun 30, 2027 · University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)
NIH RePORTER · NIH RePORTER 11134565 (opens the source filing in a new tab)
- Grant
P30 · $219k · non-dilutive
Sep 15, 2006UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · NIA · award ends Jun 30, 2027 · Leadership Administration Core
NIH RePORTER · NIH RePORTER 11134593 (opens the source filing in a new tab)
- Grant
P30 · $695k · non-dilutive
Sep 30, 1997UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAYLOR, ROBERT JOSEPH · NIA · award ends Jun 30, 2028 · Michigan Center for Urban African American Aging Research
NIH RePORTER · NIH RePORTER 11134544 (opens the source filing in a new tab)
- Grant
P30 · $372k · non-dilutive
Aug 15, 1997GEORGETOWN UNIVERSITY · PI DASH, CHIRANJEEV · NCI · award ends Apr 30, 2029 · Community Outreach and Engagement
NIH RePORTER · NIH RePORTER 11323922 (opens the source filing in a new tab)
- Grant
P30 · $108k · non-dilutive
Aug 8, 1997WAYNE STATE UNIVERSITY · PI BEEBE-DIMMER, JENNIFER L · NCI · award ends Nov 30, 2026 · Epidemiology Research Core (ERC)
NIH RePORTER · NIH RePORTER 11514604 (opens the source filing in a new tab)
- Grant
P30 · $41k · non-dilutive
Aug 8, 1997WAYNE STATE UNIVERSITY · PI BEEBE-DIMMER, JENNIFER L · NCI · award ends Nov 30, 2026 · Population Studies and Disparities Research
NIH RePORTER · NIH RePORTER 11478116 (opens the source filing in a new tab)
- Grant
P30 · $269k · non-dilutive
Mar 1, 1997RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KINNEY, ANITA Y. · NCI · award ends Feb 28, 2029 · Community Outreach and Engagement
NIH RePORTER · NIH RePORTER 11317120 (opens the source filing in a new tab)
Biodatica publishes impersonal research shown identically to every subscriber. This dossier is informational only, it is not investment advice, and the momentum and runway figures are estimates derived from public filings. The underlying records are U.S. government works. Disclosures · Data sources